Chrissy Bishop
University of Bradford, UK
Title: New insites on reporting congenital anomaly rates using primary care data from a multiethnic cohort study: The born in Bradford project
Biography
Biography: Chrissy Bishop
Abstract
Introduction:
Bradford has high rates of infant mortality for children of Pakistani origin, with congenital anomalies (CA) being the most common cause of death and disability in this group. The CA rate in Bradford is higher than the national average before age of 1 at 399 per 10,000 live births1. We linked children with CA to General Practice (GP) data, allowing prospectively collected medical information to provide promising new insights into CA research including risk factors for CA and more complete case ascertainment.
Methods:
Of 11474 babies with questionnaire data available, children with one or more CA (n=1039) were linked to their mothers GP data and compared to those without CA (n=10435). Diagnoses were classified using ICD-10 and validated by clinicians. Data for case ascertainment were compared to national CA registries. We calculated univariate and multivariate risk ratios (RRs) with 95% confidence intervals for various maternal risk factors.
Findings:
The prevalence of CA was consistent to national registries for early diagnoses, but age to diagnoses was an important factor in demonstrating increased prevalence after age 1. We found the rates slightly higher but comparable to previous rates at 461 per 10,000 live births. Only 46% of diagnoses were made before age 1, increasing significantly to 902 per 10,000 live births up to age 8. Consanguinity was found to be a risk factor for anomalies in Pakistani mothers (multivariate RR 2.2, 95% CI 1.54-3.03), and maternal age >34 years for White British mothers (multivariate RR 1.72, 95% CI 1.02-2.92).