Xia Zou
Sun Yat-sen University, China
Title: Trends and risk factors of HIV, HCV, and syphilis seroconversion among drug users in methadone maintenance treatment program in China: A seven-year retrospective cohort study
Biography
Biography: Xia Zou
Abstract
Among 9,240 participants, the overall HIV seroconversion rate was 0.20 (0.13-0.28)/100 person-years (pys), 20.54 (18.62-22.46)/100 pys for HCV, and 0.77 (0.62-0.93)/100 pys for syphilis over the study period. HIV seroconversion rate showed a moderate but non-significant annual decline of 13.34% (-42.48-30.56%) (Chi-2 trend test: p=0.369), whereas the decline of HCV seroconversion was 16.12% (5.53-25.52%) per annum (p<0.001). Syphilis seroconversionrate remained stable (p=0.540). Urine results positive for opioid predicted HIV seroconversion (≥60% versus <60%: HR=3.40, 1.07-10.85), being unmarried (HR=1.59, 1.15-2.20), injection drug use in the past 30 days (HR=2.17, 1.42-3.32), having sexual intercourse in the past 3 months (HR=1.74, 1.22-2.47) and higher daily dosage of methadone (≥60 ml versus <60 ml: HR=1.40, 1.01-1.94) predicted HCV seroconversion. Being female (HR=3.56, 2.25-5.64) and infected with HCV at baseline (HR=2.40, 1.38-8.36) were associated with subsequent syphilis seroconversion.
